The activity independent of the MTHFR gene mutation
Supports the nervous system functions
Safe methylated form of folates
The proper metabolism of homocysteine
Supports normal pregnancy development
Prevention of cardiovascular diseases
Regulation of methylation
Prevention of anaemia

Jarrow Methyl Folate is a dietary supplement containing the latest 4th generation folate, Quatrefolic®, which made up of 5-methyltetra-hydrofolate and glucosamine salt. The 4th generation folates are characterised by high activity and absorption. One capsule provides 1,000 mcg of folates.

Due to the frequent occurrence of MTHFR gene mutation in the population, attention is often drawn to the so-called active folates. These are compounds, whose activity and absorption does not depend on mutations of that gene. Folates are classified by generations, the most active folate forms are the 3rd and the newest 4th generation. According to latest research, active folates have much higher bioavailability than popular folic acid. It has been shown that the 4th generation, which is glucosamine salt, is the fastest-absorbed and has better bioavailability than the 3rd generation folates.

Methyltetra-hydrofolate is a biologically active, methylated form of folate. Folates are involved in biochemical reactions, in which they play a role of coenzymes. They are a source of one-carbon residues, needed for the proper synthesis of DNA, proteins and myelin sheaths as well as for the transformations of amino acids. Folates are particularly needed in the cells which undergo intensive divisions, i.a. in bone marrow cells or fetal tissues.

Folates reduce homocysteine levels. Homocysteine is a sulphur amino acids, whose high blood level increases the risk of cardiovascular diseases, including coronary heart disease. It also promotes the development of mental disorders. Folates are necessary for remethylation of homocysteine to methionine, resulting in reducing homocysteine levels. Numerous studies demonstrate inverse correlation between the levels of folates and homocysteine in blood.

Folates support the balance in the nervous system. Too high homocysteine level promotes the development of mental disorders and neurodegenerative diseases. Impaired folate metabolism can activate neurotoxic and apoptotic processes. It is also suggested that folate deficiencies accelerate ageing of neurons and impair synthesis of particular neuromediators. Folate deficiencies are often observed in case of particular mental disorders, such as endogenous depression, psychosis and insomnia.

The complex folate sources support the proper pregnancy and child development. The proper folate supply is an essential factor in the prevention of congenital malformations, including serious neural tube defect. These defects are unfortunately still quite often. According to experts’ recommendations, during preconception and pregnancy, women should supplement folates in form of folic acid. You should not give up on using folic acid during pregnancy, but it is worth to supplement also an active folate, which will complement the folate levels faster and effectively support folic acid action.

Folates are necessary for the proper blood formation. Because of the important role in the DNA synthesis, folates and vitamin B12 are necessary for the proper production of erythroblast nuclei. Deficiency of these compounds results in production of abnormal megaloblasts, which are then transformed to enlarged and short-lived megalocytes instead of erythrocytes. This results in development of megaloblastic anaemia.

To sum it all up, Jarrow Methyl Folate is a dietary supplement which effectively complements folic acid deficiencies. The product is recommended to complement the diet poor in folates, for people with increased demand for folates, observing impaired methylation, higher homocysteine level as well as during pregnancy and preconception (in combination with folic acid).