Life Extension

SAMe

• Improves mental well-being
• Supports detoxification
• Supports cognitive functions
• Improves joints mobility
• Supports methylation
• Helps in depression treatment
• Increases glutathione levels
• Supports liver functions
• Reduces inflammations
• Pain-killing properties
• Supports the immunity

Life Extension SAMe is a dietary supplement containing S-adenosyl methionine, a substance which naturally occurs in the body system, involved in all important biochemical processes. Each tablet contains up to 200 mg of S-adenosyl methionine and is covered with a gastro-resistant casing, which prevents damage or inactivation of the active component.

The wide spectrum of health promoting properties of SAMe allows for the use of the product for improvement in both mental and physical well-being. The supplement relieves the osteo-articular system ailments and liver dysfunctions. It is a valuable support for people suffering from depression. At the same time, it is one of the most popular nootropic agents improving cognitive functions.

S-adenosyl methionine (SAM, SAMe) is an organic compound which can be found in almost all tissues of the human body system, and its largest quantities are stored in brain and liver. It is produced from adenosine triphosphate (ATP) and methionine, with the participation of folic acid and vitamin B12.

There are 50 biochemical processes identified so far which depend on SAMe. The substance regulates all core functions: it participates in the methylation process and is the main biological donor of methyl groups in the reactions catalyzed by methyltransferases. It easily crosses the blood-brain barrier and acts directly in the central nervous system.

Antidepressant properties
SAMe relieves the symptoms of depression, and its effectiveness is similar to synthetic pharmaceuticals (e.g. imipramine). What is more, clinical studies have proven that SAMe is effective even in patients, who did not observe any improvements after standard treatment. Moreover, it does not cause any side effects characteristic for antidepressants (weight gain, dry mouth, constipation and decrease in libido). Furthermore, the action of SAMe is much faster.

These positive effects are possible due to the ability to raise the levels of serotonin and dopamine, two neurotransmitters most important for well-being. SAMe plays a core role in their production.

Improvement in cognitive functions
SAMe can be used to improve the mental capacity. As a perfect methyl group donor, it provides methyl groups to neurotransmitters, DNA, RNA phospholipids, proteins and other important elements of the body system. In this way, it helps to stimulate the multiplication and recovery of cells, supports their proper development and diversity. All this processes promote the maintenance of the proper cognitive functions.

SAMe is involved in the production of phosphatidylcholine, one of the most important substances determinating mental capacity. Its low level in the body system results in problems with acquiring new information, associating facts, concentration and in general decline in intellectual performance.

SAMe participates in the production of myelin covering the axons of nerve cells. The main function of myelin sheaths is the improvement in the ratio and the maintenance of proper conduction of nerve impulses. The efficient communication between neurons results in better knowledge acquisition and logical thinking as well as ability to associate facts and recall memories.

Supports for the osteo-articular system
SAMe is very beneficial for people suffering from the ailments of the osteo-articular system. It may be a support for the treatment of bone and joint inflammations, degeneration or arthritis.

SAMe promotes the integration of sulphate groups with proteoglycans, which are the proteins maintaining the proper functions of joint cartilage. Thanks to that it improves the production of cartilage, protects it from degeneration, increases mobility and restores the proper movement of joints.

SAMe relieves pain and reduces inflammations associated with osteoarthritis as effectively as non-steroidal anti-inflammatory drugs (NSAIDs). It inhibits the activity of inflammatory mediators, protects joints from damage resulting from the effects of TNF-alpha factor and promotes the reduction in swelling.

Liver protection
Hepatoprotective properties of SAMe result mainly in raising the level of glutathione, the most important antioxidant, which protects liver cells from oxidative damage and harmful influence of toxins.

SAMe accelerates metabolism and excretion of alcohol as well as protects hepatocytes from its toxicity. Moreover, it prevents cholestasis, which is a pathological storage of bile in the liver, and it contributes to the normalization of levels of core liver enzymes.

To sum it all up, SAMe is a unique preparation of multidirectional health promoting action. It is recommended especially for elderly people who suffer from joint degeneration and complaining about a decrease in cognitive functions. The supplement may be a valuable support or even an alternative for standard antidepressants. At the same time, it is one of the best researched substances, and its safety and effectiveness have been proven in numerous trials.